Discovery of Saccharomyces cerevisiae mating types and genetic crossing of yeast

Date or time period: 1943

Lindegren[1][2] discovered that Saccharomyces cerevisiae had two mating types, and that a haploid mating type a and haploid mating type α can mate and give rise to an a/α diploid, which, in turn, can undergo sporulation giving rise to 2 a-type and 2 α-type ascospores according to the genetic principles of Gregor Mendel


  1. Lindegren, C. and Lindegren, G. (1943) Legitimate and illegitimate mating in Saccharomyces cerevisiae. Genetics 28: 81
  2. Lindegren, C. and Lindegren, G. (1943) A new method for hybridizing yeast. Proc. Natl. Acad. Sci. USA 29 306-308