| Date or time period | Event | 
| Pre-historic period | The history of winemaking parallels that of civilisation | 
| 6000 BC | Wine emerges with civilization from the East | 
| 5000 BC | Ancient winemaking spreads from Egypt and Phoenicia | 
| 5000 BC | Wine references in Egypt and Phoenicia | 
| 4500 BC | Wine produced in Greece, Crete and the far East | 
| 1500 BC | Wine first arrived in southern Europe and northern Africa | 
| 500 BC | Wine produced in India, China and most parts of Europe | 
| 200 | Romans began with wood cooperage and the use of barrels | 
| 400 | Progress in wine technology slowed down | 
| 1500 | Introduction of vines and winemaking in the New World | 
| 1600s | Rapid increase in use of cork as a seal for wine bottles | 
| 1630s | First report of glass bottles for wine storage | 
| 1680 | First microscopic observation of yeast cells | 
| 1700s | Appearance of vintage, age-worthy wines | 
| 1750s | First cork factory | 
| 1768 | Hydrometer readings of sugar levels in wine | 
| 1769 | First isolation of tartaric acid from grapes | 
| 1789 | First demonstration that ethanol formed by the fermentation of sugar | 
| 1799 | Grape sugar identified as glucose | 
| 1800s | Bordeaux mixture for downy control | 
| 1815 | Quantification of sugar fermentation | 
| 1823 | First measurement of alcohol | 
| 1824 | First record of grape hybridisation | 
| 1824 | First reference to oak chips | 
| 1847 | First control measure for powdery mildew | 
| 1850s | Introduction of the first vine pruning system | 
| 1858 | First observation of bacteria in wine | 
| 1860s | Application of sulfur dust to control fungal disease and outbreak of phylloxera | 
| 1862 | Introduction of the process of pasteurisation | 
| 1864 | First observation of reduction in wine acidity | 
| 1864 | First proof that fermentation is carried out by living cells of yeast | 
| 1866 | First recognition of importance of wine phenolics | 
| 1875 | Accurate measurement of alcohol by ebulliometery | 
| 1875 | Introduction of the concept of phylloxera-resistant rootstock | 
| 1878 | Discovery of enzymes | 
| 1881 | Acceptance grafting scions onto rootstocks | 
| 1888 | Isolation of pure yeast cultures | 
| 1890 | Inoculation of wine fermentation with pure yeast cultures | 
| 1890s | Grapevine breeding and emergence of French hybrids | 
| 1890s | In California, rootstocks were imported | 
| 1891 | Bacteria identified as cause of malic acid conversion | 
| 1892 | Ripper method developed for measuring SO2 in wine | 
| 1895 | Tannin concentration in wine | 
| 1897 | Discovery of the ‘fermentation enzyme’ | 
| 1900 | Inoculation of wine with malolactic bacteria | 
| 1901 | Method development for measurements of wine composition | 
| 1910s | Flor yeast introduced | 
| 1911 | Ratio of fruit weight to wood recognised as the key to vine productivity and fruit quality | 
| 1920s | Centrifuge technology for clarifying juice and wine first used in Australia | 
| 1920s | Vine improvement programs | 
| 1925 | Ratchet basket press | 
| 1927 | SO2 analysis | 
| 1930s | Cold stabilisation of wine first applied | 
| 1930s | Importance of pH control in winemaking recognised | 
| 1930s | Introduction of grape yield forecasting | 
| 1930s | Pectolytic enzymes introduced | 
| 1930s | Vine breeding programs | 
| 1934 | Bentonite for wine clarification | 
| 1935 | Closterovirus recognized as the cause of leaf roll | 
| 1935 | Elucidation of the life cycle of Saccharomyces cerevisiae yeast | 
| 1935 | Yeast propagation introduced | 
| 1936 | Soil-borne nematodes recognised as damaging pests of grapevines | 
| 1940s | Bench-grafting large-scale production of resistant rootstocks | 
| 1940s | Degree day index for regional climate classification | 
| 1940s | Diatomaceous earth filtration introduced | 
| 1940s | New disease control measures | 
| 1940s | Rootstock propagation in nurseries formalised | 
| 1940s | The use of refrigeration in fermentation | 
| 1942 | Ethylene polymer cork-like product patented | 
| 1943 | Control of bacterial spoilage of fortified wines by pH | 
| 1943 | Discovery of Saccharomyces cerevisiae mating types and genetic crossing of yeast | 
| 1943 | Problem of bacterial spoilage in fortified wine solved by Fornachon | 
| 1946 | Heliothermic Index developed | 
| 1947 | Vine prunings mainly ceased to be burnt in the vineyard | 
| 1948 | First stainless steel grape receival area | 
| 1950s | Development of drip irrigation systems | 
| 1950s | Development of gas chromatography to allow study of aroma compounds | 
| 1950s | First attempts to mechanise grape harvesting | 
| 1950s | Grapevine fanleaf virus described | 
| 1950s | Improved filtration | 
| 1950s | Inert gas cover | 
| 1950s | Introduction of refrigeration allows production of high quality white wines in warmer climates | 
| 1950s | MLF observed in Australian wines | 
| 1950s | The release of nematode-resistant rootstocks | 
| 1950s | Tissue analysis for determination of nutrient status | 
| 1950s | Use of small oak barrels becomes prevalent in New World winemaking | 
| 1952 | Introduction of non-sulfur powdery mildew control agents | 
| 1953 | First major vineyard planted | 
| 1953 | Postulation of the double helical structure of DNA | 
| 1953 | Pressure fermentation tanks | 
| 1956 | Bag-in-box idea for wine packaging patented | 
| 1957 | First horizontal air bag press | 
| 1958 | Establishment of Foundation Plant Material Service in California | 
| 1958 | First clonal selection program initiated in Australia | 
| 1959 | First automatic bottling line introduced | 
| 1960 | Development of first membranes for reverse osmosis | 
| 1960 | Introduction of balanced pruning | 
| 1960 | The concept of a horizontal drum pressed was patented | 
| 1960s | Commercial use of growth regulators | 
| 1960s | Continuous improvement of refrigerated stainless steel fermentors | 
| 1960s | Development of high-level grafting techniques for top-working | 
| 1960s | Development of the first vertical stroke action mechanical harvesters | 
| 1960s | Elucidation of canopy management principles | 
| 1960s | Indicator vines used for indexing of grapevine viruses | 
| 1961 | First continuous centrifuge | 
| 1961 | Introduction of broad-spectrum fungicides for powdery mildew control | 
| 1962 | First 'Potter' fermenters introduced | 
| 1962 | First Botrytis sweet Semillon made | 
| 1962 | Importation of vine cultivars | 
| 1962 | Use of temperature controlled wine storage facility | 
| 1964 | Further understanding of phenolic composition of grapes and wine | 
| 1964 | Stainless steel fermenters introduced | 
| 1965 | Application of bag-in-box packaging of wine | 
| 1965 | Development of metal twist-off bottle closures | 
| 1965 | Introduction of automated remuage for sparkling wine production | 
| 1965 | Introduction of first commercial active dry wine yeast starter cultures | 
| 1966 | Establishment of the complete genetic code | 
| 1966 | First new varieties brought into South Australia | 
| 1966 | New analytical method for the isolation of wine tannins | 
| 1967 | First use of sprinklers for frost control | 
| 1967 | Flow-tap for bag-in-box packaging patented | 
| 1968 | The beginning of the development of salt-tolerant rootstocks | 
| 1969 | Dried yeast introduced | 
| 1969 | First machine harvester brought to Australia | 
| 1970s | Canopy management expanded across a range of climates | 
| 1970s | Drip irrigation widely adopted in Australia | 
| 1970s | Emergence of minimal pruning | 
| 1970s | Further improvements in mechanical harvesting technology | 
| 1970s | Importance of pH in red winemaking | 
| 1970s | Improvements in mechanical harvesting technology | 
| 1970s | Lyre trellis system developed | 
| 1970s | Selection and comparison of Vitis vinifera clones became standard practice in Australia | 
| 1970s | Stelvin sealed wines introduced into the Australian market | 
| 1970s | Understanding of fundamental grapevine biology improved | 
| 1972 | Agglomerate corks | 
| 1972 | Development of the Potter drainer and fermentor | 
| 1972 | Import of first mechanical harvester in Australia and rapid uptake of mechanisation | 
| 1972 | Rotary drum vacuum filter developed | 
| 1973 | Introduction of new fungicides for disease control in vineyards | 
| 1973 | Rotary fermentors developed | 
| 1973 | Spread of grapevine yellows elucidated | 
| 1973 | The first cloning experiments with recombinant DNA | 
| 1974 | The potent flavour compound damascenone identified in grapes | 
| 1975 | Flavour chemistry of Muscat varieties understood | 
| 1975 | Mechanical pruning of grapevines | 
| 1975 | Methoxypyrazines first identified in grapes | 
| 1976 | The first use of NIR for alcohol measurements | 
| 1977 | Chemical age index for wine published | 
| 1978 | Continuous screw press patented | 
| 1978 | First transformation of yeast with cloned DNA | 
| 1978 | Infrared aerial photography used for phylloxera detection | 
| 1979 | Link between H2S production and must nitrogen content revealed | 
| 1980 | Climatic classifications published | 
| 1980 | Foamed thermoplastic resin cork patented | 
| 1980s | A new biotype of phylloxera kills grafted vines | 
| 1980s | Development of regulated deficit irrigation strategies | 
| 1980s | Development of the Te-Kauwahata twin-tier and Scott-Henry training systems | 
| 1980s | First DNA techniques for reliable wine yeast strain identification | 
| 1980s | First hybrid rootstocks released | 
| 1980s | Further development of mechanical pruning systems | 
| 1980s | Interactive physiological effect of rootstocks on fruit composition | 
| 1980s | Mechanisation of leaf removal, shoot positioning and lifting of foliage wires | 
| 1980s | Minimal pruning shown to be valid in cool climates | 
| 1980s | Relationship between pH and SO2 | 
| 1980s | Release of improved French hybrid varieties | 
| 1980s | Research on the effect of harvesters on the dispersal and spread of crawlers | 
| 1980s | Research on the effect of mechanised crop thinning, pruning and harvesting | 
| 1980s | Role of grape derived precursors in releasing monoterpenes recognised | 
| 1980s | Rootstock resistant to all phylloxera biotypes released | 
| 1980s | Screw cap wines largely removed from the Australian market | 
| 1981 | Continuous starter culture production | 
| 1981 | Patent for diaphragm press filed | 
| 1982 | Cork taint | 
| 1983 | First use of HCN as dormancy breaker for improved budburst | 
| 1984 | Wine aroma wheel developed | 
| 1984 | Yellow speckle viroid detected in grapevine | 
| 1985 | A patent filed for the use of reverse osmosis for alcohol reduction | 
| 1988 | Foundation of the Australian Vine Improvement Association | 
| 1988 | Patent filed for Spinning Cone technology for alcohol removal and aroma capture | 
| 1990 | Application of ethephon and paclobutralzol to inhibit vegetative growth | 
| 1990 | First genetically engineered prototype wine yeast | 
| 1990s | Australian producers begin to return to the screw cap | 
| 1990s | Bio-pesticides | 
| 1990s | DNA profiling used to determine parentage of 'old' grape varieties | 
| 1990s | Development of Partial Rootzone Drying (PRD) irrigation | 
| 1990s | Development of integrated mechanical pruning and harvesting systems | 
| 1990s | Development of mechanical shoot thinning machines | 
| 1990s | Development of more precise barrel prunning mechanical systems | 
| 1990s | Glycosidase enzymes for liberating bound flavour commercially applied | 
| 1990s | Introduction of precision agriculture through remote sensing technologies | 
| 1990s | New MLF cultures introduced | 
| 1990s | Recognition that numerous flavour compounds in wine derive from glycoside precursors | 
| 1990s | The Smart-Dyson system for control of bunch exposure developed | 
| 1990s | The release broad-spectrum strobilurin fungicides | 
| 1991 | Development micro-oxygenation technology | 
| 1992 | Biologically-effective day degrees adjusted for latitude and daily temperature range | 
| 1992 | New hybrid wine yeast strains developed and commercialised | 
| 1993 | Commercialisation of the first freeze-dried cultures of malolactic | 
| 1993 | DNA fingerprinting used for grape variety identification | 
| 1994 | Patent filed for a reverse osmosis process to remove unwanted substances | 
| 1995 | Flavour precursor G-G assay developed | 
| 1996 | Characterisation of the malolactic enzyme system | 
| 1996 | Genetic blueprint of first Saccharomyces cerevisiae revealed | 
| 1996 | Method for measuring grape colour developed | 
| 1997 | First systematic review of stuck fermentation | 
| 1998 | Amino acid precursors in grapes release potent thiol compounds | 
| 1999 | Benchmark trial of different bottle closures | 
| 2000 | Clare Valley producers bottle 2000 vintage Riesling under screw cap | 
| 2000 | First application of consumer acceptance testing in wine research | 
| 2000s | Approaches to minimise risks of spoilage by Brettanomyces | 
| 2000s | Better understanding of the relationship between tannin and quality | 
| 2000s | Commercialisation of a flavour-enhancing mixture of three wine yeasts | 
| 2000s | Commercialisation of a wine yeast for the reduction of ethyl carbamate formation | 
| 2000s | Commercialisation of a wine yeasts for the reduction of H2S | 
| 2000s | Commercialisation of malolactic wine yeast | 
| 2000s | Commercialisation of new interspecific yeast strains | 
| 2000s | Construction of a wine yeast deletion library | 
| 2000s | Detection of compounds in smoke affected grapes & wine | 
| 2000s | Development of flavour-enhancing wine yeast prototypes | 
| 2000s | Development of in-bottle measurement of oxygen | 
| 2000s | Development of low-alcohol wine yeast prototypes | 
| 2000s | Discovery of thiols in fruity white wines | 
| 2000s | Elucidation of relationship between anthocyanin degradation and berry temperature | 
| 2000s | Flavour scalping by some bottle closures | 
| 2000s | Links between composition and perceived coarseness in white wines explored | 
| 2000s | Malolactic bacteria found to increase oakiness in wine | 
| 2000s | Nitrogen management in vineyards and winery for optimal wine quality | 
| 2000s | Precision agriculture and remote sensing | 
| 2000s | Rapid spectral methods developed to analyse anthocyanins and predict tannin | 
| 2000s | Salt-tolerant rootstocks released | 
| 2000s | The use of oak chips permitted in the EU | 
| 2000s | Tools with which to manage environmental conditions | 
| 2000s | Varietal differentiation of grape juices by protein fingerprinting | 
| 2005 | Development of a simple tannin assay | 
| 2005 | Genetic blueprint of the first malolactic bacterial strain revealed | 
| 2007 | Discovery of rotundone in peppery Shiraz | 
| 2007 | Genetic blueprint of the first grapevine variety revealed | 
| 2008 | Elucidation of relationship between berry and wine quality | 
| 2008 | Genetic blueprint of the first wine yeast strain revealed | 
| 2009 | Chemical characterisation of wild ferment wines | 
| 2009 | Crystal structure for grape haze-forming protein solved | 
| 2009 | Discovery of cineole as the cause of minty eucalypt character in red wine | 
| 2009 | Expanded consumer preferences studies in emerging markets | 
| 2009 | First commercialisation of a true Saccharomyces bayanus yeast for enhancing wine flavour | 
| 2009 | Genome sequencing and comparisons among grape varieties and clones | 
| 2009 | Genome sequencing and comparisons among malolactic bacteria | 
| 2009 | Genome sequencing and comparisons among wine yeasts | 
| Beyond 2010 | Automated expert systems | 
| Beyond 2010 | Continuous systems | 
| Beyond 2010 | Genetically improved bacteria, yeasts and grapevines | 
| Beyond 2010 | Heat-proof management systems | 
| Beyond 2010 | Native plants as cover crops | 
| Beyond 2010 | Objective quality measures | 
| Beyond 2010 | Objective definitions of wine styles | 
| Beyond 2010 | Predictive Biology | 
| Beyond 2010 | Real-time yield estimations | 
| Beyond 2010 | Real-time, automated irrigation systems | 
| Beyond 2010 | Robotic pruners and other devices | 
| Beyond 2010 | Selective mechanical harvesters | 
| Beyond 2010 | Synthetic Biology | 
| Beyond 2010 | ‘Omics, bioinformatics and Computational and Systems Biology |